Experiment 1 ; Uniformity test of diameter,thickness and hardness

EXPERIMENT 1: 

Uniformity test of diameter,thickness and hardness.

OBJECTIVE:

1.      To determine the uniformity of tablets in diameter, thickness and hardness.

PROCEDURE:

10 tablets are chosen and examined using Tablet Testing Instrument, PTB 311 (PHARMATEST) for their uniformity in diameter, thickness and hardness. The deviation of individual unit from the mean diameter is calculated and ensured to not exceeding ± 5% for tablets with diameter of less than 12.5 and ± 3% for diameter of 12.5 mm or more. 

RESULTS:

TABLET	DIAMETER (mm)	THICKNESS (mm)	HARDNESS
1	13.13	5.49	113.9
2	13.16	5.46	108.4
3	13.16	5.50	131.1
4	13.13	5.50	128.3
5	13.11	5.49	116.6
6	13.18	5.50	115.3
7	13.13	5.45	112.2
8	13.12	5.50	100.1
9	13.14	5.47	102.2
10	13.13	5.47	110.5

CALCULATION:

Mean of diameter (mm) = Total diameter of all tablets / 10

 = (13.13 + 13.16 + 13.16 + 13.13 + 13.11 + 13.18 + 13.13 + 13.12 + 13.14 + 13.13) / 10

   = 13.139 mm

Percentage (%) = │ (Experimental diameter – Mean diameter) / Mean diameter│ X 100

TABLET	PERCENTAGE (%)
1	0.0685
2	0.1598
3	0.1598
4	0.0685
5	0.2207
6	0.3120
7	0.0685
8	0.1446
9	0.0076
10	0.0685

DISCUSSION:

                    In this experiment, 10 tablets of the same type are used to test their uniformity in diameter, thickness and hardness. From the results obtained, it showed that the diameter and thickness of each tablet are slightly same comparing to each other. The diameter of the tablets is at range of 13.13 mm to 13.18 mm whereas the thickness of the tablets is at range of 5.45 mm to 5.50 mm. This indicates that the tablets have achieved the uniformity in diameters and thickness. For the hardness of each tablets, the result obtained proved that one tablet will have its own hardness which is it might be same or different to other tablets. Commonly, the hardness of the individual tablet will be slightly different compared to others.

                  The uniformity of diameter of the tablets can be further proven with the percentage difference that has been calculated. Theoretically, tablets with diameter 12.5 mm or more than 12.5 mm would have not more than 3% of individual deviation from the average diameter. From the results obtained, it showed that all the tablets have achieved percentage difference below than 3%. This means that each tablets had obey the theoretical value of standard diameter.

CONCLUSION:
                     Tablets with the same type are commonly have slightly similar or uniform value in their diameter and thickness. However, it has distinct value in measuring their harness as one unit of tablet has different hardness compared to other tablets. In conclusion, the uniformity of tablets in diameter, thickness and hardness are important in assessment of quality of tablets.

REFERENCES:

1. http://hussain-ku.blogspot.com/2010/11/quality-control-tests-for-tablets.html
2. http://www.sadgurupublications.com/ContentPaper/2012/4_133_JCCPS_2(1)2012_P.pdf
3. http://books.google.com.my/books?id=KorasAtSpfoC&pg=PA4&lpg=PA4&dq=performance+test+doses+(disintegration+and+dissolution)&source=bl&ots=A2677PXCjn&sig=NBlcIE3dg6e7hsbOiwjXTedPKsY&hl=en&sa=X&ei=NgW0Uv-dCofzrQflwICwDw&ved=0CGQQ6AEwBA#v=onepage&q=performance%20test%20doses%20(disintegration%20and%20dissolution)&f=false